Abstract: Objective To establish an effective treatment method of chemotherapy with implantable port system in pulmonary carcinoma to treat the patient with pulmonary carcinoma at the advanced stage. The effectiveness, complication and the influence on the patient of this method were comparatively studied with the traditional vein chemotherapy. Methods The pulmonary carcinoma patients were divided into two groups (50 patients per group). In the experimental group, the chemotherapy medicine was injected into the pump body while the drugs were input by vein in the vein chemotherapy control group. Results The tumor size in the experimental group decreased more and showed significant difference (P<0.05) from that in the control group. The general appearance after chemotherapy in the experimental group was better than that in the controlled group (P<0.05). The numbers of the white blood cells, the CD4/CD8 and the NK cells in the experimental and control groups showed significant difference (P<0.05) after 7 and 14 days of treatments. Conclusion Compared with the traditional method, it was observed that the tumor sized decreased more, the general appearance became better and the decrease of white blood cells, CD4/CD8 and NK cells was lower in the method with implantable port system.