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罗红霉素治疗癌症恶病质的实验[J]. 肿瘤防治研究, 2010, 37(09): 1022-1024. DOI: 10.3971/j.issn.1000-8578.2010.09.012
引用本文: 罗红霉素治疗癌症恶病质的实验[J]. 肿瘤防治研究, 2010, 37(09): 1022-1024. DOI: 10.3971/j.issn.1000-8578.2010.09.012
Experimental of Influence of Roxithromycin on Cancer Cachexia[J]. Cancer Research on Prevention and Treatment, 2010, 37(09): 1022-1024. DOI: 10.3971/j.issn.1000-8578.2010.09.012
Citation: Experimental of Influence of Roxithromycin on Cancer Cachexia[J]. Cancer Research on Prevention and Treatment, 2010, 37(09): 1022-1024. DOI: 10.3971/j.issn.1000-8578.2010.09.012

罗红霉素治疗癌症恶病质的实验

Experimental of Influence of Roxithromycin on Cancer Cachexia

  • 摘要: 目的 研究罗红霉素对癌症恶病质小鼠的治疗作用并探讨其可能机制。方法 于皮下接种小鼠结肠腺癌Colon26细胞于雄性BALb/c小鼠后9天建立癌症恶病质模型。实验动物分为三组:正常对照组、模型对照组、恶病质罗红霉素治疗组。观察癌症恶病质鼠治疗后的一般指标(体质量、去瘤体质量、食物摄入量、左侧腓肠肌重量),血清营养指标(白蛋白、血糖、甘油三酯),并用ELISA法检测血清肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)、白介素-6(interleukin-6, IL-6)水平。结果 荷瘤小鼠去瘤体质量明显下降,严重的代谢紊乱(白蛋白、血糖水平降低、甘油三酯水平升高),血清TNF-α、IL-6水平升高。罗红霉素治疗组与模型组相比左侧腓肠肌重量增加,血糖升高,甘油三酯降低,血清TNF-α降低。结论 罗红霉素具有抗癌症恶病质的作用,其机制可能是通过降低升高的TNF-α产生。

     

    Abstract: Objective To investigate the effects of the roxithromycin on cancer cachexia and to study the related mechanism using mice with cancer cachetic as animal model. MethodsMale BALB/c mice bearing colon 26 adenocarcinoma for 9 days were served as models of cancer cachexia. The mice were divided into three groups: healthy control group, cancer cachexia with saline group, and cancer cachexia with roxithromycin (RM) group. Physiological conditions, bodyweight and food intake were documented every day. Serum levels of cytokine and nutritional markers were detected seven days after treatment. Results Tumor-bearing caused a decrease of body weight and metabolic disturbance after the removal of tumor. Serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were significantly elevated accompanied with nutrition depletion in tumor-bearing mice.In the RM-treated group,the gastrocnemius muscle weight was increased, the concentration of serum glucose was increased,and the serum TNF-α and triglyce ride were decreased. Conclusion RM may have the potentials to moderate cancer cachexia state and adjust metabolic disorder through down-regulating the serum level of TNF-α.

     

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