hMLH1、转化生长因子β受体Ⅱ在食管癌中的表达及意义

焦云娟; 杨晓煜; 张哲莹; 崔静; 王永霞; 张景航; 赵卫星

doi:10.3971/j.issn.1000-8578.2010.08.017

hMLH1、转化生长因子β受体Ⅱ在食管癌中的表达及意义

453003河南新乡，新乡医学院基础医学院病理教研室

详细信息

通讯作者:
赵卫星

中图分类号: R735.1
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出版历程
- 收稿日期: 2009-03-08
- 修回日期: 2009-04-24
- 刊出日期: 2010-08-24

Expression and Significance of hMLH1 and TGFβRⅡ in Esophageal Squamous Cell Carcinoma

Department of Pathology， Xinxiang Medical University， Xinxiang 453003, China

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Corresponding author:
ZHAO Wei-xing

摘要

摘要: 目的：探讨hMLH1、转化生长因子β受体Ⅱ在食管黏膜上皮癌变过程中的意义及相关性。方法采用免疫组织化学方法,检测正常食管黏膜上皮及食管不同病变组织中hMLH1、转化生长因子β受体Ⅱ的表达情况, 并分析其与临床病理参数的相关性。结果：hMLH1在食管鳞状细胞癌中的阳性表达率（14.92%）显著低于正常食管黏膜组织(95.00%)、非典型增生组织（71.43%）、原位癌组织（68.00%）,组间比较差异具有统计学意义（P<0.05）。转化生长因子β受体Ⅱ在食管鳞状细胞癌中的阳性表达率（9.52%）显著低于正常食管黏膜组（85.00%）非典型增生组织（61.90%）、原位癌组织（64.00%）组间比较差异具有统计学意义（P<0.05）。hMLH1 和转化生长因子β受体Ⅱ阳性表达率与肿瘤的分化程度密切相关；且两者在食管癌组织中的表达具有相关性。结论：hMLH1和转化生长因子β受体Ⅱ的异常表达与食管鳞状上皮癌变有关；转化生长因子β受体Ⅱ可能是hMLH1的靶基因。
- hMLH1 /
- 转化生长因子β受体Ⅱ /
- 食管癌 /
- 非典型增生 /
- 免疫组织化学
Abstract: Objective：To investigate the significance and relation of transforming growth factor-β type Ⅱ receptor gene and hMLH1 gene in carcinogenesis of esophageal mucosa epithelium. Methods：The expression of transforming growth factor-β type Ⅱ receptor gene and hMLH1 gene in normal esophageal mucosa epithelium and variant lesions were detected by immunohistochemistry,and their correlation with clinicopathological parameters were analysed as well. Results：The positive expression rate (14.29%) of hMLH1 in esophageal squamous cell carcinoma is significantly lower than that in normal esophageal mucosa epithelium (95.00%)，atypical hyperplasia（71.43%）, carcinoma in situ （68.00%）（P<0.05）;which showed statistical significance. The positive expression rate (9.52%) of TGFβRⅡ in esophageal squamous cell carcinoma is significantly lower than that in normal esophageal mucosa epithelium(85.00%)，atypical hyperplasia （61.90%）, carcinoma in situ （64.00%）（P<0.05）;which showed statistical significance. The positive expression of hMLH1 and Transforming growth factor-β type Ⅱ receptor had close correlation with the differentiation of esophageal carcinoma;the expression of hMLH1 and TGFβRⅡ in esophageal squamous cell carcinoma had correlation. Conclusion ：The abnormal expression of hMLH1 protein may be related with the carcinogensis of the esophageal squamous cell. Transforming growth factor-β type Ⅱ receptor may be the target gene of hMLH1.
- hMLH1 /
- TGFβRⅡ /
- Esophageal squamous cell carcinoma /
- Atypical hyperplasia /
- Immunohistochemistry