Abstract: Objective To investigate the expression and significance of SH2-B in ovarian serous carcinoma. Methods The expression of SH2-B was detected in ovarian serous tumor by using immunohistoch-emistry assay, and the correlation between SH2-B and clinical stage, pathological grade and age was analyzed. Results SH2-B expressed in cytoplast and cytoplasm of tumor, mainly in cytoplasm.The positive rate of SH2-B in benign tumor, borderline tumor and serous carcinoma was 28%, 48% and 91%, respectively,and there was significant difference within them(P<0.05). The expression rate of positive cells and the score of staining intensity of SH2-B in serous carcinoma were significantly higher than that in borderline tumor and benign tumor (P<0.01).The expression of SH2-B in serous carcinoma revealed that there was no correlation between SH2-B expression and age(P>0.05) except for clinical stage and pathological grade(P<0.05). Conclusion SH2-B may be related to the occurrence and development of ovarian cancer.