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肾透明细胞癌caveolin-1的表达及其与微血管密度的相关性

伍 健, 费绍华, 丁 珺, 贺玉洁

伍 健, 费绍华, 丁 珺, 贺玉洁. 肾透明细胞癌caveolin-1的表达及其与微血管密度的相关性[J]. 肿瘤防治研究, 2010, 37(05): 555-557. DOI: 10.3971/j.issn.1000-8578.2010.05.018
引用本文: 伍 健, 费绍华, 丁 珺, 贺玉洁. 肾透明细胞癌caveolin-1的表达及其与微血管密度的相关性[J]. 肿瘤防治研究, 2010, 37(05): 555-557. DOI: 10.3971/j.issn.1000-8578.2010.05.018
WU Jian, FEI Shao-hua, DING Jun, HE Yu-jie. Expression of caveolin-1 inRenalClear Cell Carcinoma and Its Correlation with Microvascular Density[J]. Cancer Research on Prevention and Treatment, 2010, 37(05): 555-557. DOI: 10.3971/j.issn.1000-8578.2010.05.018
Citation: WU Jian, FEI Shao-hua, DING Jun, HE Yu-jie. Expression of caveolin-1 inRenalClear Cell Carcinoma and Its Correlation with Microvascular Density[J]. Cancer Research on Prevention and Treatment, 2010, 37(05): 555-557. DOI: 10.3971/j.issn.1000-8578.2010.05.018

肾透明细胞癌caveolin-1的表达及其与微血管密度的相关性

详细信息
  • 中图分类号: R737.11

Expression of caveolin-1 inRenalClear Cell Carcinoma and Its Correlation with Microvascular Density

  • 摘要: 目的 探讨肾透明细胞癌caveolin-1的表达与临床病理学意义,同时探讨caveolin-1表达与微血管密度(MVD)的相关性。 方法 应用免疫组织化方法(SP法)检测43例肾透明细胞癌caveolin-1的表达,同时通过标记CD34的表达来检测微血管密度。 结果 肾透明细胞癌caveolin-1表达的阳性率为67.4%(29/43),caveolin-1表达与性别和年龄无关,但是与肿块大小、临床TNM分期、病理核分级和生存时间有关( P <0.05);caveolin-1表达阳性组MVD明显高于caveolin-1表达阴性组( P <0.05)。 结论 caveolin-1的表达有助于肾癌预后的评价,且caveolin-1可能参与调节肿瘤血管的形成。

     

    Abstract: Objective To investigate both the clinicopathologic significance of the expression of caveolin-1 in the renal clear cell carcinoma and the corelation between the expression of caveolin-1 and microvessel density. Methods The expression of caveolin-1 detected byimmunohistochemistry method, while the microvessel density was assessed using immunohistochemistry method by marking CD34. Results In the renal clear carcinoma, the positive rate of caveolin-1 was 67.4%, the overexpression of caveolin-1 was not related with gender and age, but was related with clinicopathologic parameter, such as tumor sizes, clinical TNM stage, nuclear stage and survival time( P <0.05). The MVD of cases with positive caveolin-1 was significantly higher than those without caveolin-1 expression( P <0.05). Conclusion The expresion of caveolin-1 is helpful in the prognostic evalution of renal clear cell carcinoma and it may be involved in the angiogenesis of the renal clear cell carcinoma.

     

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出版历程
  • 收稿日期:  2009-01-03
  • 修回日期:  2009-11-01
  • 刊出日期:  2010-06-24

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