消痰散结方对荷S180肉瘤小鼠蛋白质代谢的影响

林晖明; 魏品康; 许 玲; 巨大维; 顾坚忠; 白辰光

doi:10.3971/j.issn.1000-8578.2010.05.010

消痰散结方对荷S180肉瘤小鼠蛋白质代谢的影响

1. 200003上海，第二军医大学附属长征医院中医科;2.中国科学院上海实验动物中心;3.第二军医大学附属长海医院病理科

详细信息

通讯作者:
魏品康

中图分类号: R73-36；R730.52；R730.6
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出版历程
- 收稿日期: 2008-12-08
- 修回日期: 2009-09-26
- 刊出日期: 2010-06-24

Effect of Xiaotansanjie Recipe on Protein Metabolic of S180 Bearing Mice

1．Department of Traditional Chinese Medicine，Changzheng Hospital Affiliated to Second Military Medical University，Shanghai 200003，China；2．Shanghai Laboratory Animal Center，CAS；3．Department of Pathology，Changhai Hospital Affiliated of Second Military Medical University

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Corresponding author:
WEI Pin-kang

摘要

摘要: 目的运用荷S180小鼠模型，观察消痰散结方改善肿瘤蛋白质代谢状况的作用，探索其作用机制。方法将40只小鼠随机分为消痰散结方组（A组）、化疗（喃氟啶）组（B组）、0.9%氯化钠溶液组（C组），对照组（D组），前三组进行S180肉瘤皮下接种造模；4周后，观察各组体重，血清生化检测总蛋白、白蛋白和C-反应蛋白（CRP）水平，免疫组化观察骨骼肌结构及骨骼肌NF-κB 的表达。结果消痰散结方可升高荷瘤鼠血清总蛋白、白蛋白水平，下调血清CRP水平，对骨骼肌结构具有保护作用。结论消痰散结方可以改善肿瘤蛋白代谢状况，其可能途径是通过调节肝脏的蛋白代谢。
- 消痰散结方 /
- 肿瘤 /
- 蛋白代谢 /
- 小鼠
Abstract: Objective To investigate the effects of Xiaotansanjie Recipe on protein metabolic of S180 bearing mice and discuss its mechanism. Methods Forty mice were randomly divided into 4 groups: XiaotanSanjie Recipe group(A group);FT-207 group (B group); NS group(C group); normal group. The mice were sacrificed on the 4th week. The weights of mice were measured. Total protein, albumin and CRP of blood were detected . The expression of muscle NF-κB was analyzed by immunohistochemistry． Results Xiaotansanjie Recipe can up-regulate total protein and albumin of blood, down-regulate blood CRP in mice. It also can protect the structure of the muscle. Conclusion Xiaotansanjie Recipe adjusted the protein metabolic abnormalities in tumor-bearing mice．It might be one of the mechanism responsible for its anti-tumor effects.
- Xiaotansanjie Recipe /
- Tumor /
- Protein metabolic /
- Mice