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氟达拉宾联合瘤苗抗小鼠RMA淋巴瘤的实验

李 翔, 高全立, 买 玲

李 翔, 高全立, 买 玲. 氟达拉宾联合瘤苗抗小鼠RMA淋巴瘤的实验[J]. 肿瘤防治研究, 2010, 37(05): 519-521. DOI: 10.3971/j.issn.1000-8578.2010.05.008
引用本文: 李 翔, 高全立, 买 玲. 氟达拉宾联合瘤苗抗小鼠RMA淋巴瘤的实验[J]. 肿瘤防治研究, 2010, 37(05): 519-521. DOI: 10.3971/j.issn.1000-8578.2010.05.008
LI Xiang, GAO Quan-li, MAI Ling. Experiment of Anti-MA Lymphoma of Mice by Fludarabine Peritoneal Injection Associated with Inactivated Lymphoma Vaccine[J]. Cancer Research on Prevention and Treatment, 2010, 37(05): 519-521. DOI: 10.3971/j.issn.1000-8578.2010.05.008
Citation: LI Xiang, GAO Quan-li, MAI Ling. Experiment of Anti-MA Lymphoma of Mice by Fludarabine Peritoneal Injection Associated with Inactivated Lymphoma Vaccine[J]. Cancer Research on Prevention and Treatment, 2010, 37(05): 519-521. DOI: 10.3971/j.issn.1000-8578.2010.05.008

氟达拉宾联合瘤苗抗小鼠RMA淋巴瘤的实验

详细信息
    通讯作者:

    买 玲

  • 中图分类号: R733.4

Experiment of Anti-MA Lymphoma of Mice by Fludarabine Peritoneal Injection Associated with Inactivated Lymphoma Vaccine

  • 摘要: 目的:研究注射用化疗药物氟达拉宾(Fludarabine)联合瘤苗治疗小鼠RMA淋巴瘤的作用与机制。方法:以C57BL/6小鼠为研究对象,通过Western blot分析实验组与对照组小鼠脾脏组织中Foxp3基因的表达,并观察各组小鼠的肿瘤生长与生存期。结果:氟达拉宾组与对照组相比,能够下调Foxp3基因的表达。氟达拉宾联合瘤苗能有效抑制肿瘤的生长速度,并提高荷瘤小鼠的生存期,与对照组相比差异有统计学意义( P <0.05)。结论:氟达拉宾联合瘤苗能够增强小鼠机体抵抗肿瘤的能力,并能够延长小鼠生存期。

     

    Abstract: Objective:To observe the anti- RMA lymphoma effect and mechanism by Fludarabine injection associated with inactivated lymphoma vaccine. Methods:Use C57BL/6 mice as a target, Foxp3 genes in spleens were identified by Western blot, at the same time, the tumor growth and survival of the Fludarabine group and the control group were observed. Results:Fludarabine could downregulate the expression of Foxp3 gene,and fludarabine associated with vaccine could not only inhibit the tumor growth but also improve survival of animals ( P <0.05). Conclusion:The experiment revealed that Fludarabine associated with vaccine can strengthen the ability to antagonize tumor, and prolog life span of tumor-bearing mice.

     

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出版历程
  • 收稿日期:  2009-01-07
  • 修回日期:  2009-08-19
  • 刊出日期:  2010-06-24

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