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乳腺癌患者手术和化疗前后血清HER2 ECD 水平的变化

廖 天, 陆云飞

廖 天, 陆云飞. 乳腺癌患者手术和化疗前后血清HER2 ECD 水平的变化[J]. 肿瘤防治研究, 2010, 37(04): 435-437. DOI: 10.3971/j.issn.1000-8578.2010.04.018
引用本文: 廖 天, 陆云飞. 乳腺癌患者手术和化疗前后血清HER2 ECD 水平的变化[J]. 肿瘤防治研究, 2010, 37(04): 435-437. DOI: 10.3971/j.issn.1000-8578.2010.04.018
LIAO Tian, LU Yun-fei. Changes of Serum HER-2 Extracellular Domain Levels of Pre- and Post-Surgery and Chemotherapy in Breast Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2010, 37(04): 435-437. DOI: 10.3971/j.issn.1000-8578.2010.04.018
Citation: LIAO Tian, LU Yun-fei. Changes of Serum HER-2 Extracellular Domain Levels of Pre- and Post-Surgery and Chemotherapy in Breast Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2010, 37(04): 435-437. DOI: 10.3971/j.issn.1000-8578.2010.04.018

乳腺癌患者手术和化疗前后血清HER2 ECD 水平的变化

详细信息
    通讯作者:

    陆云飞

  • 中图分类号: R737.9

Changes of Serum HER-2 Extracellular Domain Levels of Pre- and Post-Surgery and Chemotherapy in Breast Cancer Patients

More Information
    Corresponding author:

    LU Yun-fei

  • 摘要: 目的 探讨乳腺癌患者手术、化疗前后血清HER2 ECD水平变化的临床意义。 方法 用双抗体夹心ELISA法(酶联免疫吸附法)检测乳腺癌患者及其配对手术、化疗前后血清HER2 ECD水平,进行统计分析。 结果 乳腺癌患者血清HER2 ECD水平与正常人和良性乳腺病患者有明显差异(P<0.01);手术后59 例乳腺癌患者血清HER2 ECD水平89.8%(53/59)下降,10.2%(6/59)升高,而33例良性乳腺病患者69.7%(23/33)下降,30.3%(10/33)升高, 两者差异有统计学意义(P<0.05);血清HER2 ECD水平升高组(8/59)对化疗反应率100.0%(8/8),而非升高组(51/59)对化疗反应率74.51%(38/51),两者无差别(P>0.05)。 结论 动态监测乳腺癌患者血清HER2 ECD水平对评价其手术、化疗疗效有一定的临床提示意义。

     

    Abstract: Objective To evaluate the clinical implication of variations in serum HER2/neu extracellular domain (ECD) levels before and after treatment of breast cancer patients. Methods Serum HER2/neu extracellular domain (ECD) levels of 59 breast cancer patients before and after surgery or chemotherapy were assayed by enzyme-linked immunosorbent assay (ELISA). Results Significant different HER2 ECD levels were found between breast cancer and healthy women and benign mastopathia(P<0.01). 89.8% ( 53/59 ) of 59 breast cancer patients and 69.7% ( 23/33) of 33 benign mastopathia patients with decreasing levels of serum HER2/neu ECD after surgery showed difference between the two groups(P<0.05).100.0%(8/8)of patients with increasing levels of HER2 ECD (8/59)and 74.51%(38/51)of patients with non-increasing levels of HER2 ECD (51/59)responded to chemotherapy(P>0.05), showing no difference between the two groups. Conclusion Kinetic monitoring of the changes of serum HER-2/neu ECD levels in breast cancer patients may represent a valuable tool for evaluating clinical response to surgery and chemotherapy.

     

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出版历程
  • 收稿日期:  2008-12-11
  • 修回日期:  2009-07-12
  • 刊出日期:  2010-05-24

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