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非霍奇金淋巴瘤预后相关因素探讨

唐文台, 郭瑞珍

唐文台, 郭瑞珍. 非霍奇金淋巴瘤预后相关因素探讨[J]. 肿瘤防治研究, 2010, 37(03): 322-325. DOI: 10.3971/j.issn.1000-8578.2010.03.022
引用本文: 唐文台, 郭瑞珍. 非霍奇金淋巴瘤预后相关因素探讨[J]. 肿瘤防治研究, 2010, 37(03): 322-325. DOI: 10.3971/j.issn.1000-8578.2010.03.022
TANG Wen-tai, GUO Rui-zhen. Exploration of Prognostic Factors onNon-Hodgkin's Lymphoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 322-325. DOI: 10.3971/j.issn.1000-8578.2010.03.022
Citation: TANG Wen-tai, GUO Rui-zhen. Exploration of Prognostic Factors onNon-Hodgkin's Lymphoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 322-325. DOI: 10.3971/j.issn.1000-8578.2010.03.022

非霍奇金淋巴瘤预后相关因素探讨

详细信息
  • 中图分类号: R733.4

Exploration of Prognostic Factors onNon-Hodgkin's Lymphoma

  • 摘要: 目的 探讨贵州地区与NHL预后相关的因素。 方法 病例随访,并从不同的侧面分析NHL的预后相关因素。 结果 (1)随访24例NK/T,Survivin阳性组的平均生存时间(14.1月)短于阴性组(26.1月),差异有统计学意义(P=0.03); 43例BCL,Survivin阳性组的平均生存时间(19.1月)短于阴性组(27.5月),差异有统计学意义(P=0.013)。(2)随访58例NHL,肿瘤组织有坏死组平均生存时间(7.4月)短于无坏死组(24.4月),差异有统计学意义(P<0.005)。(3)随访53 例NHL, p53、bcl-6双阳性组平均生存时间(18.9月)短于非双阳性组(32.1月),差异有统计学意义(P<0.05)。(4)随访5例鼻部NK/T,平均生存时间7.4月。 结论 凋亡抑制基因的高表达、肿瘤组织的坏死、鼻部发生的NK/T以及p53、bcl-6双表达与NHL的预后有相关性, NHL的预后与多种因素有关。

     

    Abstract: Objective To explore the prognostic factors onnon-Hodgkin,s lymphoma(NHL) in Guizhou district. Methods Follow-up studying and analyzing of prognostic factors in several aspects were performed in over 100 cases of non-Hodgkin,s lymphoma. Results (1) In 24 cases of NK/T cell lymphoma(NK/TCL),there were significant difference in mean survival time between the survivin positive group and negative group (14.1 and 26.1monthsrespectively, P=0.03). In 43 cases of B cell lymphoma (BCL),there were significant difference in mean survival time between the survivin positive group and negative group (19.1 and 27.5months respectively, P=0.013). (2) In 58 cases of NHL,there were significant difference in mean survival time between the necrosis group and non-necrosis group (7.4 and 24.4monthsrespectively,P<0.005).(3) In 53 cases of NHL,there were significant difference in mean survival time between the p53,bcl-6 double-positive group and non-double-positive group (18.9 and 32.1monthsrespectively,P<0.05). (4) In 5 cases of nasal NK/T cell lymphoma, the mean survival time was 7.4months. Conclusion Thefactorson theprognosis ofNHL included the high-expression ofapoptosis-suppressing genes, necrosis of tumor tisssues,occurrence ofNK/T celllymphoma, and dual expression ofp53and bcl-6.

     

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出版历程
  • 收稿日期:  2008-11-26
  • 修回日期:  2009-11-01
  • 刊出日期:  2010-04-24

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