Abstract: Objective To observe the ascites control effects and short-term clinical efficacy and toxicity in the treatment of primary peritoneal carcinoma with cisplatin (DDP), fluorouracil (5-Fu) alternating abdominal perfusion and systemic chemotherapy of ECF (epirubicin, cisplatin, 5- fluorouracil). Methods DDP,5-Fu alternating intraperitoneal perfusion plus ECF program intravenous chemotherapy, one cycle of 21 days for a total of 6~8 cycles, was evaluate at least after 4 cycles. Results In 15 cases, the ascites control rate was 86.6%, and the total effective rate (RR) 86.6%, including complete remission (CR) (26.6%), and partial remission (PR) (60%). The major toxicity was Ⅱ~Ⅲ myelosuppression. Conclusion DDP and 5-Fu alternating intraperitoneal perfusion plus ECF in the treatment of primary peritoneal carcinoma has better control of ascites and satisfactory short -term efficacy,slight toxicity light and low-cost. It can be used as first-line treatment programs for primary peritioneal carcinoma.