高级搜索

替莫唑胺治疗复发性胶质瘤的疗效分析

晏 怡, 唐文渊, 邓朝霞

晏 怡, 唐文渊, 邓朝霞. 替莫唑胺治疗复发性胶质瘤的疗效分析[J]. 肿瘤防治研究, 2010, 37(01): 91-94. DOI: 10.3971/j.issn.1000-8578.2010.01.025
引用本文: 晏 怡, 唐文渊, 邓朝霞. 替莫唑胺治疗复发性胶质瘤的疗效分析[J]. 肿瘤防治研究, 2010, 37(01): 91-94. DOI: 10.3971/j.issn.1000-8578.2010.01.025
YAN Yi, TANG Wen-yuan, DENG Zhao-xia. Efficacy of Temozolomide in Treatment of Recurrent Glioma[J]. Cancer Research on Prevention and Treatment, 2010, 37(01): 91-94. DOI: 10.3971/j.issn.1000-8578.2010.01.025
Citation: YAN Yi, TANG Wen-yuan, DENG Zhao-xia. Efficacy of Temozolomide in Treatment of Recurrent Glioma[J]. Cancer Research on Prevention and Treatment, 2010, 37(01): 91-94. DOI: 10.3971/j.issn.1000-8578.2010.01.025

替莫唑胺治疗复发性胶质瘤的疗效分析

详细信息
  • 中图分类号: R730.264;R730.53

Efficacy of Temozolomide in Treatment of Recurrent Glioma

  • 摘要: 目的 观察并评价替莫唑胺对复发性胶质瘤的临床疗效。 方法 35例复发性胶质瘤患者,14例首次使用替莫唑胺治疗(F组),10例再次或多次使用替莫唑胺治疗(R组),11例从未使用(N组),定期临床随访、分析所有纳入病例的治疗反应。 结果 疗效评价指标包括完全缓解(complete response,CR),部分缓解(partial response,PR),稳定(stable disease,SD),进展(progressive disease,PD)及肿瘤进展时间(time of tumor progression, TTP),半年肿瘤无进展数比和半年生存数比。其中F组的PR+SD较R组与N组高且差异有统计学意义(P<0.05),F组的半年生存例数比为13/15,显著高于R组的5/10(P<0.05)和N组的4/11(P<0.01)。 结论 替莫唑胺化疗对初次用药的复发性胶质瘤有效,但对再次使用替莫唑胺治疗组中的病例疗效不明显。

     

    Abstract: Objective To evaluate the efficacy of Temozolomide in the treatment of recurrent glioma. Methods Thirty-five patients with recurrent glioma were enrolled in our study. According to the history of temozolomide administration, 35 patients were divided into group F (the patients first treated with temozolomide), group R (the patients re-treated with temozolomide), and group N (the patients without chemotherapeutic history). Clinical evaluations and assessments of tumor response were performed every 2 months. Results In group F, the complete response(CR) was not observed, partial response (PR) in 6 cases, stable disease(SD)in 10 cases, and 5 cases developed progressive disease(PD). In group R, the complete response(CR) was not observed, partial response (PR) was observed in 2 cases, stable disease(SD)in 4 cases, and 9 cases developed progressive disease(PD). In group N, the complete response(CR) was not observed, partial response (PR) was observed in 1 cases, stable disease(SD)in 5 cases, and 9 cases developed progressive disease(PD). Therein, (PR+SD) in group F was significantly higher than group R and group N respectively (both P<0.05). Cases of 6 month overall survival in group F was more than those in group R (P<0.05) and group N (P<0.01). Conclusion Initial use of temozolomide is effective for recurrent glioma, but the curative effectiveness of temozolomide re-administration is not obvious.

     

计量
  • 文章访问数:  2354
  • HTML全文浏览量:  17
  • PDF下载量:  555
  • 被引次数: 0
出版历程
  • 收稿日期:  2008-09-15
  • 修回日期:  2009-03-11
  • 刊出日期:  2010-02-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭