Abstract: Objective To investigate the influence of different treatment model on therapeutic effect of locally advanced breast cancer. Methods Medical records of 278 patients with stage T3～4，N0～3 breast cancer (AJCC TNM staging 2002) were analyzed retrospectively. Among them, 82 patients were treated with radiotherapy followed by chemotherapy of six cycles, 102 patients received sandwich therapy (chemotherapy of three cycles + radiotherapy + chemotherapy of three cycles), and the surplus 94 patients were treated with chemotherapy of three cycles followed by local radiotherapy. The analysis of related factors of local recurrence, distant metastasis and survival rate were performed with SPSS10.0 software. Results The difference of five-year survival rate in the three groups was not statistically significant. The local recurrence in sandwich group was lower than that in radiotherapy after chemotherapy group, the distant metastasis in sandwich group was lower than that in chemotherapy after radiotherapy group, and the occurrence of toxic and adverse reaction in sandwich group was less frequent than the other two groups. Conclusion Sandwich therapy may be an ideal choice for adjuvant postoperative treatment.