Abstract: Objective To investigate the applications and treatment results of 3-dimensional conformal radiotherapy combined with concurrent cisplatin(DDP) weekly chemotherapy (3DCRT+CT) for postoperative thoracic lymph nodes recurrence (PTLNR)of esophageal cancer. Methods 98 patients with PTLNR of esophageal cancer without adjuvant chemoradiotherapy were randomly devided into 3DCRT alone and 3DCRT+CT groups. 60~70Gy/30~35Fx was delivered to the PTV with whole-range 3DCRT in 2 groups.In addition,those patients of 3DCRT+CT group were dripped cisplatin(DDP) 30mg/m² weekly. Results 3DCRT+CT group showed a better response rate, that was 91.8% vs. 73.5%(P=0.016). Furthermore, the survival rates at 1 and 3 years of 3DCRT+CT were superior to that of 3DCRT alone (85.7% vs. 69.4%，P=0.032；46.9% vs. 28.6%，P=0.038). However,no significant difference in the overall survival rates at 5 years was observed between the two groups (14.3% vs. 8.2%，P=0.051). 5 patients died of distance metastasis in 3DCRT+CT group and 13 patients in 3DCRT (P=0.036). Acute radiation-induced esophagitis and granulocytopenia in 3DCRT+CT group were more frequent (P＜0.05),while there was no significant difference in the late toxicity. Conclusion 3DCRT combined with concurrent chemotherapy is an available and feasible option for PTLNR of esophageal cancer,and can increase the tumor local control rate, decrease the distance metastasis rate and even be advantageous to long-term survival rate.