Abstract: Objective To evaluate the therapeutic effects of interventional transarterial thermochemotherapy on the intermediate and advanced pancreatic cancer patients. Methods Thirty patients were randomly divided into two groups. Patients in experimental group were treated with interventional thermo-chemotherapy; patients in control group were given conventional transarterial interventio-nal chemo-therapy alone. Therapeutic outcome of those two groups were analyzed for the percentage of tumor responded to the treatment, favored clinical response and side effects, cumulative survival rate and median survival time. Results The experimental group showed the tumor response rate of 57.1% vs. 37.5% of control group, the clinically favored response rate of 85.7% vs. 75.0%, the pain relief rate of 100% vs. 75.0%. The thermo-chemo therapy also yielded 6, 9, 12-month survival rate at 92.9%, 85.7% and 21.4% in the experimental group vs. 75%, 50% and 12.5% in the chemotherapy treatment alone group, respectively. Conclusion In comparison with transarterial chemotherapy treatment alone, interventional transarterial thermo-chemotherapy can deliver superior therapeutic results and could be a safe and effective treatment of intermediate and advanced pancreatic cancer.