Abstract: Objective To investigate the expression of IGF-ⅠR and the relationship between clinical stage, pathological grade, lymph node metastasis etc in laryngeal squamous cell carcinoma(LSCC). Methods The expression of IGF-ⅠR protein were detected by immunohistochemistry technique in 60 cases of LSCC, 25 cases of adjacent nontumorous laryngeal epithelium,10 cases of normal laryngeal epithelium. Results The positive rate of IGF-ⅠR expression in LSCC was significant higher than that in the normal laryngeal epithelium and adjacent nontumorous laryngeal epithelium(P<0.05). IGF-ⅠR positive expression was stronger in stageⅢ～Ⅳof LSCC, cervical lymph node metastasis cases and well differentiation of LSCC than that in stageⅠ～Ⅱ, non-lymph node metastasis cases and poor/mediate differentiation respectively (P<0.05). Conclusion There was overexpression of IGF-VR in the laryngeal carcinoma, which may play an important role in the carcinogenesis and development of LSCC. Examination of IGF-ⅠR expression has a great significance in estimating prognosis of patients with LSCC.