MMP-7及uPA在卵巢浆液性囊腺癌中的表达和意义
Expression and Significance of Matrix Metalloproteinase-7 and uPA in Serous Ovarian Cancers
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摘要: 目的 探讨基质金属蛋白酶-7（MMP-7）蛋白和uPA蛋白在正常卵巢组织和卵巢浆液性肿瘤组织中的表达及与卵巢浆液性囊腺癌浸润转移的关系。 方法 应用免疫组化法检测40例卵巢浆液性囊腺癌，12例卵巢浆液性囊腺瘤和10例正常卵巢组织中MMP-7 和uPA的表达情况。 结果 MMP-7蛋白和uPA蛋白在正常卵巢组织中无阳性表达。MMP-7在卵巢浆液性囊腺瘤和卵巢浆液性囊腺癌中表达的阳性率差别有统计学意义(16.7% vs67.5%,χ2=9.670，P=0.002<0.05)。uPA在卵巢浆液性囊腺癌和卵巢浆液性囊腺瘤的表达率分别是72.5%和33.3%（χ2=6.107，P=0.013<0.05），两者之间差异有统计学意义。MMP-7和uPA的阳性表达率与患者年龄无显著相关性(P=0.554>0.05和P=0.077>0.05)；随卵巢浆液性囊腺癌病理分级、FIGO分期增高、盆腔浸润、腹膜淋巴转移，MMP-7和uPA表达明显增强（P<0.05）且MMP-7 与uPA表达之间存在正相关(rs=0.573,P<0.05)。 结论 MMP-7 和uPA在卵巢浆液性肿瘤的发生发展中起了重要作用，且两者相互激活，共同促进卵巢浆液性囊腺癌的浸润和转移。Abstract: Objective To investigate the expression of matrix metalloproteinase-7(MMP-7)and uPA in serous ovarian tumors as well as their relationships with clinical characteristics. Methods The expression of MMP-7 and uPA proteins were examined with immunohistochemical technique in the specimens from serous cystadenomas, serous cystadenocarcinomas and normal ovaries. Results No MMP-7 and uPA was detected in normal ovaries. The positive rates of MMP-7 and uPA were significantly higher in serous cystadenocarcinomas of ovary than in serous cystadenomas of ovary (87.5% vs. 16.7%, P=0.001<0.05; 85% vs 33.3%, P=0.001<0.05). MMP-7 expression was up-regulated significantly according to the increasing of clinical disease period raised, decreasing of tissue classification, invasion of pelvic and transferring of lymph node. Similar overexpression pattern of uPA was also found in these situations with a positive correlation with MMP-7. Conclusion MMP-7 and uPA may play an important role in the progression of serous ovarian tumors and they interacted with each other to improve the metastasis of serous cystadenocarcinomas of ovary.
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