细胞周期素H与细胞周期素依赖性激酶7在卵巢癌组织中的表达及其意义

章颖; 马向涛; 袁桂兰

doi:10.3971/j.issn.1000-8578.2009.04.013

细胞周期素H与细胞周期素依赖性激酶7在卵巢癌组织中的表达及其意义

1.100080 北京海淀医院妇科,2.普外科

详细信息

中图分类号: R737.31
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出版历程
- 收稿日期: 2008-01-21
- 修回日期: 2009-01-05
- 刊出日期: 2009-05-24

Overexpression and Potential Correlations of Cyclin H and Cyclin Dependent Kinase 7 in Human Ovarian Carcinoma

1.Department of Obstetrics and Gynecology, Beijing Haidian Hospital, Beijing 100080, China, 2.Department of Surgery

摘要

摘要: 目的探讨Cyclin H与CDK7在卵巢癌中的作用。方法应用Western blot 检测40例卵巢癌患者标本中肿瘤组织、正常组织中Cyclin H与CDK7表达情况，免疫组织化学法检测Cyclin H与CDK7在细胞水平的分布。结果卵巢癌组织中Cyclin H与CDK7表达水平明显增高，分别为正常组织的3.9倍、2.9倍（P＜0.05）；Cyclin H表达水平与FIGO分期相关（P＜0.05）；Cyclin H与CDK7在卵巢癌组织中表达情况呈线性相关，相关系数为0.401，P<0.05。结论 Cyclin H与CDK7在卵巢癌组织中呈高表达，Cyclin H与CDK7可能在卵巢癌发生中起重要作用。
- 卵巢癌 /
- 细胞周期素 /
- 转移
Abstract: Objective The purpose of this study is to investigate the potential role of Cyclin H /Cyclin Dependent Kinase 7 in tumorigenesis of ovarian carcinoma. Methods Tissue samples from 40 patients with ovarian carcinoma were selected for studying Cyclin H/CDK7 protein expression, by using western blot analysis. Results Cyclin H and CDK7 protein levels were found increased in ovarian cancer as compared with those in normal tissues, with a median increasing value of 3.9 and 2.9-fold respectively (P<0.05). It was found that up-requlations of Cyclin H and CDK7 were tightly related to FIGO stage in ovarian cancer (P<0.05). Expression of Cyclin H was found in a positive linear correlation fashion with CDK7 in tumor (r=0.401, P<0.05). Conclusion Overexpression of Cyclin H/CDK7 may play an important role in tumorigenesis of ovarian carcinoma, and the possible mechanism needs further investigation.
- Ovarian neoplasm /
- Cyclin /
- Metastasis