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22例肺肉瘤样癌临床分析

Clinical Analysis of Pulmonary Sarcomatoid Carcinoma——22 Cases Report

  • 摘要: 目的本研究拟探讨肺肉瘤样癌的临床特点、诊断方法和预后。方法回顾性分析22例经手术切除的肺肉瘤样癌患者的临床资料,生存率计算采用Kaplan-Meier法,生存率比较采用Log-rank检验,多因素回归分析采用Cox风险比例模型。结果本组患者中位年龄63岁;男女比例为8∶3;大多数患者有吸烟史。全组的中位生存期为0.96年,5年累积生存率为26.5%。Ⅰ、Ⅱ和Ⅲ期患者的5年累积生存率分别为60.0%、0和11.1%(P=0.0014)。pT和病理切片含有坏死是独立的预后影响因素(P<0.05)。结论肺肉瘤样癌易发生于有吸烟史的老年男性,手术后容易早期出现远地转移而死亡,pT3以及病理含有坏死的患者预后差。

     

    Abstract: Primary sarcomatoid carcinoma of the lung is a rare malignancy.This study was to investigate its clinical characteristics, diagnosis and prognosis. Methods The data of patients with pulmonary sarcomatoid carcinoma between Jan. 2001 and Dec. 2006 were reviewed. The survival rates was calculated with Kaplan-Meier method and compared with Log-rank method, Cox proportional hazards model was used for multivariate analysis. Results Totally 22 patients were eligible, including 16 male and 6 female, most of whom had smoking history. The median age was 63. The 5-year survival rate was 26.5% with a median overall survival of 0.96 year. The 5-year survival rates of patients in stage Ⅰ,Ⅱand Ⅲ were 60.0%,0 and 11.1%(P=0.0014),respectively. Only T stage and necrosis were independent poor prognostic factors( P<0.05). Conclusion Most of patients with lung sarcomatoid carcinoma are older males, who has heavy smoking history. Early postoperative distant metastasis is the first reason caused death. The prognosis of the patients with pT3 and necrosis is poor.

     

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