Abstract: To investigates the relationship importance of FGFR3 and VEGF, in prognos and angiogenesis in patients with Non-Hodgkin's lymphoma（NHL）. Methods Expression of FGFR3,VEGF and CD105 in 62 specimens of NHL and 40 specimens of reactive lymphoid hyperplasia （RLH） were detected by immunohistochemistry Envision. Results Positive rate of FGFR3 expression was 58.06% in NHL tissue, and 5% in RLH tissue. The expression of CD105 was significant difference between NHL and RLH tissue（P<0.05）. VEGF was over-expression in NHL tissue (75.81%) and dramaticly related with histology grade (indolent or aggressive) and International Prognostic Factors (IPI) (P<0.05). FGFR3 and CD105 staining in NHL tissue were significant correlation with clinical stage, extronodal infiltration and IPI (P<0.05 and P<0.001). The Spearman rank correlation assay indicated, positive correlation of FGFR3 with both VEGF (r= 0.326，P<0.05) and CD105 (r=0.567，P<0.001) expression in NHL. Conclusion Over expression of FGFR3 and its positive correlation with VEGF and CD105 in NHL tissue revealed that FGFR3 maybe up-regulate the expression of VEGF which involved in angiogenesis and invasion of NHL.