Abstract: Objective To study the therapeutic effects of Fuerkang Injection on transplanted hepatoma in mice，so as to provide the drug efficacy basis for development of new preparations. Methods The hepatoma H₂₂S and A type tumor cells were injected to the axilla subcutaneous and intraperitoneal of mice. Each of mice was inoculated with 2×10⁶ tumor cells，The mice were divided into groups randomly in the next day. Experimental group were intravenous or intraperitoneal injected with Fuerkang Injection 315，157.5，78.75mg/(kg·d) respectively for 10 days. Tumor inhibitory rate and survival extending rate of mice were calculated respectively. Results The inhibitory rate of Fuerkang Injection at high dose,middle dose and low dose group to hepatoma H₂₂S type solid tumor were 49.36%，39.10%，21.50% respectively. The mice survival extending rate to hepatoma H₂₂ A type ascites tumor were 82.19%，65.18%，50.61%. The results of repeated experiment for 2 times were similar to that of the above. Conclusion Fuerkang Injection hase significant curative effect on transplanted hepatocellular carcinoma in mice.