微管引流灌注绿脓杆菌制剂联合顺铂治疗 恶性胸腔积液临床观察

微管引流灌注绿脓杆菌制剂联合顺铂治疗恶性胸腔积液临床观察

摘要: 目的　评价微管引流灌注绿脓杆菌制剂联合顺铂治疗中等量或大量恶性胸腔积液的疗效。方法　将50 例中等量或大量恶性胸腔积液行微管胸腔闭式引流术,胸腔积液引净后注入绿脓杆菌制剂5 ml 和顺铂80mg。结果　CR18 例(36 %), PR21 例(42 %), 有效率78 %(39/ 50), 中位生存期248 d ;引流量(1500～6000 ml) 。结论　微管引流灌注绿脓杆菌制剂联合顺铂治疗中等量或大量恶性胸腔积液疗效佳,且安全、方便、易行,值得推广。

Abstract: Objective 　To evalulate the clinical efficacy of int rapleural minicatheter drainage and int rapleu2 ral injection with p seudomonas aeruginosa preparation and cisplatin in the t reatment of malignant pleural effusion. Methods 　50 patient s with malignant pleural effusion were t reated with int rapleural minicatheter drainage and int rapleural injection with p seudomonas aeruginosa preparation and cisplatin. Results 　The effective rate and median survival were78 %(39/ 50) and 228 days. Conclusion 　This study shows that in2 t rapleural minicatheter drainage and int rapleural injection with pseudomonas aeruginosa preparation and cisplatin may be the best way to cont rol malignant pleural effusion.