紫杉醇白蛋白微粒治疗晚期乳腺癌临床观察
Albumin2Bound Particles in Treatment with Advanced Breast Cancer
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摘要: 目的 比较紫杉醇白蛋白微粒和以聚氧乙烯蓖麻油为溶剂的紫杉醇治疗晚期乳腺癌的疗效和不良反应。方法 共收治晚期乳腺癌21 例,随机分为治疗组和对照组。治疗组紫杉醇白蛋白微粒每次剂量260 mg/ m2, 对照组聚氧乙烯蓖麻油为溶剂的紫杉醇每次剂量175 mg/ m2, 均为每3 周重复1 次。对照组化疗前常规给予地塞米松、西米替丁和苯海拉明预防过敏反应。两组患者各接受了至少4 个周期的治疗,每2 个周期评价一次疗效。结果 治疗组9/ 9 例获得CR + PR, 对照组为7/ 12 例。两组均未发生过敏反应,主要不良反应是神经毒性和粒细胞减少。结论 紫杉醇白蛋白微粒与以聚氧乙烯蓖麻油为溶剂的紫杉醇相比,疗效相当,治疗组在未进行预防过敏反应处理的情况下,无一例发生过敏反应。Abstract: Objective To compare the efficacy and the adverse reactions between albumin2bound particles and polyethylated castor oil2based paclitaxel in t reatment of advanced breast cancer. Methods Twenty2 one patient s were randomly divided into t reatment and cont rol group s with 32week cycles . The dose of t reatment group was 260 mg/ m2, which was 175 mg/ m2 in cont rol group . In cont rol group, dexametha2 sone, cimetidine and diphenhydramine were given before chemotherapy to prevent allergic reactions. Two groups of patient s received at least four cycles of t reatment, with assessment of every two cycles. Results In t reatment group, 9/ 9 cases were CR or PR, and in cont rol group was 7/ 12 cases. No allergic reactions in two group s. The main adverse reactions were neurotoxicity and neut ropenia. Conclusion By compare albumin2bound particles and polyethylated castor oil2based paclitaxel, the efficacy was similar, and in t reatment group, allergic reactions didn't occur without any preventive t reatment s of allergic reactions.
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