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Ezrin、CD44在胃癌组织中的表达及其相关性

李莹杰, 陶晓峰, 贺岩, 付红

李莹杰, 陶晓峰, 贺岩, 付红. Ezrin、CD44在胃癌组织中的表达及其相关性[J]. 肿瘤防治研究, 2008, 35(03): 188-190. DOI: 10.3971/j.issn.1000-8578.1834
引用本文: 李莹杰, 陶晓峰, 贺岩, 付红. Ezrin、CD44在胃癌组织中的表达及其相关性[J]. 肿瘤防治研究, 2008, 35(03): 188-190. DOI: 10.3971/j.issn.1000-8578.1834
LI Ying-jie, TAO Xiao-feng, HE Yan, FU Hong. Expression and Correlation of Ezrin and CD44 in Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(03): 188-190. DOI: 10.3971/j.issn.1000-8578.1834
Citation: LI Ying-jie, TAO Xiao-feng, HE Yan, FU Hong. Expression and Correlation of Ezrin and CD44 in Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(03): 188-190. DOI: 10.3971/j.issn.1000-8578.1834

Ezrin、CD44在胃癌组织中的表达及其相关性

详细信息
  • 中图分类号: R735. 2

Expression and Correlation of Ezrin and CD44 in Gastric Carcinoma

  • 摘要: 目的探讨Ezrin、CD44在胃癌组织中的表达情况及其与临床病理参数之间的关系。方法采用免疫组化法检测50例胃癌组织、25例胃粘膜不典型增生和25例正常胃粘膜中Ezrin、CD44的表达并加以分析。结果①Ezrin在正常胃粘膜、不典型增生和胃癌中的阳性表达率分别为28.0%、36.0%和86.0%。CD44在正常胃粘膜、不典型增生和胃癌中的阳性表达率分别为0、16.0%和60.0%。Ezrin、CD44在正常胃粘膜、不典型增生和胃癌中的表达率逐渐上升,差异有统计学意义(P〈0.01)。②Ezrin、CD44的表达程度均与胃癌的临床分期、淋巴结转移有关(P〈0.05),与胃癌的分化程度无关(P〉0.05)。③Ezrin和CD44的表达之间呈正相关(P〈0.01)。结论Ezrin、CD44在胃癌中的高表达与胃癌的临床分期和淋巴结转移有关,二者的联合检测可能成为预测胃癌转移及预后的重要指标。

     

    Abstract: Objective  To investigate the expression of Ezrin and CD44 and their correlations with clinical2 pathological parameters in gast ric carcinoma. Methods  The expression of Ezrin and CD44 in 50 speci2 mens of gast ric carcinoma, 25 specimens of gast ric epithelial dysplasia and 25 specimens of normal gast ric tissues were detected by immunohistochemist ry method. Results  ①In normal gast ric tissues, gast ric dysplasia and gast ric carcinoma, the percentage of Ezrin positive expression was 28. 0 %, 36. 0 % and 86. 0 %, respectively, the percentage of CD44 expression was 0, 16. 0 % and 60. 0 %. The expression of Ezrin and CD44 increased gradually in normal gast ric tissues, gast ric dysplasia and gast ric carcinoma. The difference has a statiftical significance ( P < 0. 05) . ②The expression of both Ezrin and CD44 was correlated to clinical stage, metastasis of lymph node, and there were substantial differences ( P < 0. 01), but theses were not correlated to carcinoma differentiation ( P > 0. 05) . ③ The expression of Ezrin was positively correlated to that of CD44 in gast ric carcinoma ( P < 0. 01) . Conclusion  The expression of Ezrin and CD44 was correlated to clinical stage and metastasis of lymph node. Joint examination of these two parameters is useful for forecast metastasis and prognosis of gast ric carcinoma.

     

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出版历程
  • 收稿日期:  2007-03-18
  • 修回日期:  2007-10-18
  • 刊出日期:  2008-03-04

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