EGFR、COX-2的表达以及MVD与早期非小细胞肺癌预后的相关性

EGFR,COX-2 Expression Status and Microvessel Density Correlated to Prognosis in Early Stage Non-small Cell Lung Cancer

摘要: 目的研究EGFR(表皮生长因子受体)、COX2(环氧合酶2)和MVD(微血管密度)与早期非小细胞肺癌(NSCLC)的无病生存期之间的关系。方法回顾性分析36例NSCLC术后患者的病理标本,用免疫组化的方法检测其EGFR,COX2和MVD(以CD34特异标记)的表达情况。结果EGFR和COX2的阳性表达率分别为44%和53%。这个指标均与无病生存期无显著的关系。MVD平均值为65.3,标准差为17.6,以平均值界分成高表达和低表达组。MVD高表达有导致更短的无病生存期的趋势(P=0.08)。EGFR-/COX2+/MVD高表达的早期NSCLC的无病生存期显著降低(P=0.04)。结论COX2和MVD高表达和EGFR低表达的早期NSCLC可能是高危人群,将需要更积极的辅助化疗。

Abstract: Objective We studied the association between the expression of epidermal growth factor receptor(EGFR), Cyclooxygenase-2 (COX-2), microvessel density(MVD) and disease free survival in early stage non-small cell lung cancer (NSCLC). Methods Thirty-six patients with NSCLC undergoing complete surgical resection were evaluated retrospectively. Tumor specimens were stained for EGFR, COX-2 and specific MVD marker(CD34) by Immunohistochemistry. Results EGFR and COX-2 over expressions were demonstrated in 44% and 53% ...