非小细胞肺癌中SDF-1、CXCR4的表达及临床意义

The Expressions of Stromal-Cell Derived Factor 1( SDF-1),CXC Chemokin Receptor 4(CXCR4) and their Clinical Significances in Human Non-small Cell Lung Cancer

摘要: 目的探讨基质细胞衍生因子(SDF1)及其受体CXCR4在非小细胞肺癌(NSCLC)中的表达及临床意义。方法利用免疫组织化学方法在40例NSCLC和10例对照组肺组织中检测SDF1、CXCR4的表达。结果在NSCLC中,SDF1、CXCR4的阳性表达率分别为65.00%(26/40)、45.00%(18/40),与对照组肺组织比较均有显著性差异(P<0.01,P<0.05)。SDF1、CXCR4的表达与肺癌细胞分化程度、淋巴结转移和组织学类型密切相关(P<0.01,P<0.05),而与性别、年龄无相关性(P>0.05),在NSCLC中,SDF1和CXCR4表达之间无显著相关性(P>0.05)。结论SDF1、CXCR4的表达与肺癌分化程度及转移有关,可作为临床预测肺癌患者预后的指标。

Abstract: Objective To investigate the expressions of SDF-1, CXCR4,and their clinical significance in non-small cell lung cancer. Methods SDF-1,CXCR4 were detected in 40 NSCLC tissues and 10 control group lung tissues by immunohistochemistry. Results In NSCLC tissues, positive rate of SDF-1,CXCR4 was 65.00%(26/40), 45.00%(18/40) respectively. There was significant difference in positive rate of SDF-1 and CXCR4, as compared to normal lung tissue(P< 0.01,P< 0.05). Expressions of SDF-1 and CXCR4 were closely associ...