血清CA125、CA19-9、CEA的检测在大肠癌诊断及治疗中的意义
Diagnostic and Therapeutic Value of Serum CA125,CA19-9 and CEA in Colorectal Carcinoma
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摘要: 目的探讨血清CA125、CA199、CEA的检测在大肠癌诊断及治疗中的价值。方法82例大肠癌病人均于2004年6月～2005年6月收治并手术,同时选取41例正常人做为对照组。以蛋白芯片法测定两组血清中CA125、CA199、CEA含量。结果三项指标定量检测大肠癌组明显高于对照组。其阳性率与部位、大体类型、组织类型无明显相关。三项指标阳性率Duke'sC+D期明显高于Duke'sA+B期。CA125、CA199、CEA三项指标敏感度分别为34.1%、34.1%、30.5%,特异度均为97.6%,三项联检敏感度为58.5%,特异度为92.7%,而在Duke'sC+D期,三项联检敏感度为86.8%,特异度为92.7%。结论血清CA125、CA199、CEA的检测对于大肠癌的诊断价值较低,但三项联检在Duke'sC、D期大肠癌病人诊断价值较高,有助于判断大肠癌病理分期并指导手术范围。Abstract: Objective To evaluate the diagnostic and therapeutic value of serum CA125,CA19-9 and CEA in colorectal carcinoma. Methods A total of 82 patients with colorectal carcinoma had been treated surgically between June 2004 and June 2005.The control group included 41 healthy adults.The serum CA125,CA19-9 and CEA are determined by protein chip. Results The levels of serum CA125,CA19-9 were higher in the colorectal cancer group than in the control group.The positive rates of serum CA125,CA19-9 and CEA were not associa...
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