Abstract: Objective 　To evaluate the treatment efficacy and complications of chemotherapy and late course accelerated hyperf ractionation (LCAH) plus three-dimensional conformal radiotherapy (3DCRT) for esophageal carcinoma. Methods 　The 54 patient s with esophageal carcinoma were randomized into two groups : fourty-eight patients received chemotherapy and LCAH Plus 3DCRT (3DCRT group ), 27 patients received chemotherapy plus LCA HR (control group), all patients were given with 6/ 15 MV X-ray total tumors dose was 40 Gy/20f, with conventional fractionation routine during the first two-thirds of the course, and followed by LCAHR plus 3DCRT or LCAHR, per fraction, twice daily, the total does Varied up to 68 Gy, chemotherapy regimen was LFP(CF, 52FU and DDP) . Results 　The 12and 22year survival rates in 3DCRT group and cont rol group were 85. 2 %、63. 0 % and 78. 0 %、59. 3 %(χ2 = 0. 49 、0. 08, P > 0. 05) . Conclusion 　Chemotherapy and LCAHR plus 3DCRT for esophageal carcinoma can improve the survival rate and decrease complications.