幽门螺杆菌感染与胃癌前病变及胃癌的相关性研究
Study on the Relation ship between Helicobacter Pylori Infection and Human Gastric Precancerous Lesions as well as Gastric Cancer
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摘要: 目的 从病理形态学方面探讨幽门螺杆菌 ( Helicobacter pylori,Hp)感染与胃粘膜癌前病变和胃癌的关系。方法 采用 HE、Warthin- Starry及 HID- AB( p H2 .5) - PAS染色法, 对 1 51例胃镜活检及手术切除胃标本中慢性萎缩性胃炎 ( CAG)、胃上皮不典型增生 ( gastric epithelialdysplasia,GED)、肠上皮化生 ( intestinal metaplasia,IM)及胃癌 ( Ca)组织中 Hp的感染状况进行观察, 并对 Hp的感染与各病变间的关系进行对比研究。结果 本组病例胃粘膜 Hp检出率为 66.2 %( 1 0 0 /1 51 )。 Hp的感染主要见于胃贲门以外部位, 尤其胃窦部多见, 但 Hp感染与 CAG、IMI、 型及弥漫型胃癌的发生无明显关系 ( ( P>0 .0 5), 与 GED(尤其 GED 、 级 )、IM 型和肠型胃癌的发生显著相关 ( P<0 .0 5)。结论 Hp感染是导致胃粘膜 型肠上皮化生、中度和重度不典型增生及肠型胃癌的重要致病因素, 应引起高度重视.Abstract: Objective To investigate the association of Helicobacter pylori(Hp) infection and human gastric precancerous lesions as well as cancer. Methods Hp infection conditions of chronic atrophic gastritis (CAG),gastric epithelial dysplasia(GED),intestinal metaplasia(IM) and gastric cancer (Ca) in 151 gastric endoscopic biopsy and subtotal gastrectomy specimens were detected by means of Hematoxylin Eosin,Warthin Starrry and HID AB(pH2.5) PAS stainings.Relationship between Hp infection and above mentional lesion...
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