转化生长因子-α表皮生长因子受体在上颌窦鳞癌表达的研究
Study on the Expression of TGF-A, EGFR in Human Maxillary Sinus Squamous Cell Maxillary Sinus Carcinoma
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摘要: 目的 探讨表皮生长因子受体 ( EGFR)和转化生长因子 -α( TGF-α)在上颌窦鳞癌发生的不同阶段中的表达情况。方法 应用免疫组化 LSAB法。结果 TGF-α、EGFR在上颌窦粘膜不典型增生病变、鳞癌及乳头状瘤癌变组的阳性表达率明显高于正常、单纯增生粘膜及乳头状瘤病变组 ( P<0 .0 5) ;TGF- α与 EGFR在上颌窦癌中的表达有明显的相关关系 ( P<0 .0 5) ;二者的阳性表达与患者的性别、年龄、肿瘤组织的分化程度 ( P>0 .0 5), 而与淋巴结转移及患者的生存期有关 ( P<0 .0 5)。结论 TGF- α、EGFR在上颌窦癌发生发展中起重要作用, 联合检测二者, 可作为判断上颌窦癌生物学行为和预后的参考指标.Abstract: Objective To assess the changes and possible role of expression of TGF α and EGFR in maxillary sinus carcinogenesis. Methods Immunohistochemical study using LSAB kit. Results The positive rates of TGF α and EGFR in maxillary sinus dysplasia hyperplastic epithelia,squamous cell carcinoma and papilloma with cancerous were significantly higher than that in normal and simple hyperplastic epithelia and papilloma.( P <0.05)TGF α had a close relationship to EGFR,meanwhile,there was significant correlation b...
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