结直肠癌增殖细胞核抗原表达与其预后相关因素的分析

Analysis of Proliferating Cell Nuclear Antigen Expression and Its Prognostic Factors in Colorectal Carcinoma

摘要: 目的　探讨结直肠癌增殖细胞核抗原表达与其预后因素之间的关系。方法　对 86例进展期结直肠癌患者的标本行免疫组化研究。根据增殖细胞核抗原表达的水平分析进展期结直肠癌术后的复发和生存。结果　结直肠癌增殖细胞核抗原表达与各种临床病理学因素有关。结论　当肿瘤分期增加时, 增殖细胞核抗原标志指数增加, 结直肠癌经有效切除术后其复发率和死亡率也随增殖细胞核标志指数的增加而增加.

Abstract: Objective To study the relationship between proliferating cell nuclear antigen expression and its prognostic factors in colorectal carcinoma. Methods Paraffin sections of 86 patients with advanced colorectal carcinoma was assessed by immunohistochemical study.Recurrence and survival of patients with advanced colorectal carcinoma after curative resection were analyzed in accordance with degree of PCNA expression. Results There were correlations between PCNA LI and various pathologic parameters. Conclusion PCNA...