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Ⅰ期原发性肝癌三维适形放疗的疗效评价和预后多因素分析

张洪波, 陈龙华, 吴德华, 曹小飞

张洪波, 陈龙华, 吴德华, 曹小飞. Ⅰ期原发性肝癌三维适形放疗的疗效评价和预后多因素分析[J]. 肿瘤防治研究, 2007, 34(05): 378-381. DOI: 10.3971/j.issn.1000-8578.1674
引用本文: 张洪波, 陈龙华, 吴德华, 曹小飞. Ⅰ期原发性肝癌三维适形放疗的疗效评价和预后多因素分析[J]. 肿瘤防治研究, 2007, 34(05): 378-381. DOI: 10.3971/j.issn.1000-8578.1674
ZHANG Hong-bo, CHEN Long-hua, WU De-hua, CAO Xiao-fei. Therapeutic Effects Evaluation of Three-dimensional Conformal Radiotherapy for Stage Ⅰ Primary Hepatocellular Carcinoma and Multi-factors Analysis of the Prognosis[J]. Cancer Research on Prevention and Treatment, 2007, 34(05): 378-381. DOI: 10.3971/j.issn.1000-8578.1674
Citation: ZHANG Hong-bo, CHEN Long-hua, WU De-hua, CAO Xiao-fei. Therapeutic Effects Evaluation of Three-dimensional Conformal Radiotherapy for Stage Ⅰ Primary Hepatocellular Carcinoma and Multi-factors Analysis of the Prognosis[J]. Cancer Research on Prevention and Treatment, 2007, 34(05): 378-381. DOI: 10.3971/j.issn.1000-8578.1674

Ⅰ期原发性肝癌三维适形放疗的疗效评价和预后多因素分析

详细信息
    通讯作者:

    陈龙华

  • 中图分类号: R735. 7 ;R730. 55 ;R730. 7   

Therapeutic Effects Evaluation of Three-dimensional Conformal Radiotherapy for Stage Ⅰ Primary Hepatocellular Carcinoma and Multi-factors Analysis of the Prognosis

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    Corresponding author:

    CHEN Long-hua

  • 摘要: 目的 评价三维适形放疗(3-dimensional conformal radiation therapy,3-DCRT)对Ⅰ期原发性肝癌治疗疗效及其影响预后的因素分析。方法 对41例Ⅰ期原发性肝癌患者行三维适形放疗,用kaplan—Meier统计累积生存率、COX回归模型对预后进行单、多因素分析。结果 1、2、3年累积生存率分别为95.1%、90.2%、80.5%。平均生存时间49.5月。中位生存时间56个月。治疗副反应轻微。多因素回归分析显示仅肿瘤数目对患者生存期的影响有统计学意义(P〈0.05)。结论 三维适形放疗对Ⅰ期原发性肝癌患者的治疗是安全、有效的手段,肿瘤数目、肿瘤直径是影响预后的主要因素。

     

    Abstract: Objective  To evaluate the therapeutic effect s of 3-dimensional conformal radiationtherapy for small hepatocellular carcinoma and analyze the prognostic factors. Methods  Forty-one cases of small hepatocellular carcinoma were t reated with three-dimensional conformal radiotherphy, The Kaplan-Meier was used to evaluate the survival rates, and the COX regression model was used to analysis single and multi-factors of the prognosis. Results  The overall 1-, 2-, 3-year survival rate were 95. 1 %、90. 2 %、80. 5 % respectively. Mean survival time was 49. 5 months, Media survival time was 56 months. The side effects of radiotherapy could be tolerated. Multi-factors analysis revealed that the number and the diameter of tumor were independent prognostic factors affecting the patient s'survival ( P < 0. 05) . Conclusion  The results suggest that three-dimensional conformal radiotherapy for Stage Ⅰ hepatocellular carcinoma is a relatively safe and effective method. The number and the diameter of tumor were independent prognostic factors affecting the patient s'survival.

     

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出版历程
  • 收稿日期:  2006-07-16
  • 修回日期:  2006-12-12
  • 刊出日期:  2007-05-04

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