癌症患者四种急性时相蛋白检测的临床价值

Practical Use Four Acute Phase Proteins Measurement in Patients with Cancer

摘要: 目的探讨四种急性时相蛋白在癌症患者治疗过程中继发感染的临床价值. 方法应用散射免疫比浊法对102例癌患者的C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、α1-酸性糖蛋白(AAG)和α1-抗胰蛋白酶(AAT)进行检测,并与白细胞计数(WBC)比较. 结果 CRP、SAA、AAG、AAT和WBC的异常率分别为35.3%、37.3%、17.6%、18.6%和22.5%, CRP和SAA的异常率比AAG、AAT和WBC的异常率显著升高(P＜0.05). 结论 CRP和SAA比AAG、AAT和WBC反应灵敏而迅速,在癌患者继发感染时更有诊断价值.

Abstract: Objective 　To study the clinical significance of four acute phase proteins in patient s with cancer complicated with infection. Methods 　The serum concent rations of C-reactive proteins (CRP) 、serum amyloid A protein (SAA) 、alphal2acid glycoprotein (AAG) and alphal2antit ryp sin (AAT) 102 patients with cancer were measured by nephelometry immunoassay, and compared with white blood cell (WBC) counts. Results 　The abnormal rate of CRP、SAA、AA G、AAT and WBC are 35. 3 %、37. 3 %、17. 6 %、18. 6 % and 22. 5 %, respectively, significant increases were noted the abnormal rate of CRP and SAA compared with AAG、AAT and WBC ( P < 0. 05) . Conclusion 　CRP and SAA were the sensitive markers compared with AAG、AAT and WBC, and it had the practical clinical importance for the patients with cancer complicated with infection.