Abstract: Objective 　To investigate clinical manifestation, diagnosis and treatment of skull eosinophilic granuloma. Methods 　We retrospectively studied 36 cases of skull eosinophilic granuloma during the last 10 years in our department . Results 　All patient s were confirmed as eosinophilic granuloma by postoper-ative histopathologic examination. All patient s are eusemia. Conclusion 　Skull eosinophilic granuloma is a benign disease and CT scan was important to its diagnosis. Operation can speed up the process of cure and reduce complications.