前列腺~(125)Ⅰ射粒子植入结合去势治疗C期前列腺癌(附10例报告)

Permanent ~(125)Ⅰrostate Brachytherapy Combined with Castration for Clinical Stage C Prostate Cancer(Report of 10 Cases)

摘要: 目的　探讨前列腺12 5I放射粒子植入内放疗在前列腺癌治疗中的意义。方法　依据治疗计划, 在直肠B超引导下, 经会阴穿刺植入前列腺12 5I放射粒子对 10例C期前列腺癌行三维适形内放疗并结合手术去势治疗。结果　全组手术顺利, 平均植入12 5I放射粒子 5 8粒, 平均手术时间 80分钟, 术后平均住院时间 5 .9天, 随访 9例术后 3个月结果 :前列腺体积及PSA均有不同程度降低, 前列腺平均体积由35 .2cm3 降至 2 4 .7cm3, 平均PSA由 19.8ng/ml降至0 .74ng/ml,随访 6例术后 6个月结果 :5例PSA进一步降低, 平均 0 .11ng/ml,1例升高, 由 0 .5 1ng/ml升高至 1.6 5ng/ml,无一例出现严重的并发症。结论　采用永久性放射粒子植入前列腺三维适形内放疗是一种有效、微创的治疗前列腺癌的方法。

Abstract: Objective To evaluate the clinical significance of permanent 125I prostate brachytherapy in patients with prostate cancer. Methods A total of 10 patients with clinical stage C prostate cancer underwent 3-dimensional conformal brachytherapy with transperineal ultrasound-guide 125iodine seeds prostate implantation, combined with castration. Results The median number of 125I seeds used was 58, the median operation time was eighty minutes, the median hospital stay was 5.9 days. 9 cases have b...