Midkine在食管鳞癌中的表达及其与微血管密度的关系

Expression and Significance of Midkine(MK)in Esophageal Squamous Cell Carcinoma and Correlation with Microvessel Density

摘要: 目的研究MK在食管鳞癌中的表达及与肿瘤血管形成的关系。方法采用免疫组织化学SP法检测45例食管鳞癌组织中MK的表达,同时以CD34标记微血管内皮细胞测定微血管密度(mi-crovessel density,MVD)。结果45例食管鳞癌组织中MK阳性表达率为77.8%,MK阳性的食管鳞癌组织MVD为40.43±6.27,MK阴性的食管鳞癌组织MVD为31.34±3.89,两者有显著性差异(P<0.01)。结论MK在食管鳞癌中高表达并与血管形成有关。

Abstract: Objective To study the expression of midkine in esophageal squamous cell carcinoma and the relation to angiogenesis. Methods A Immunohistochemical SP technique was used to detect the expression of MK in 45 cases who suffer from esophageal squamous cell carcinoma, Microvessel density(MVD)was also determined in endothelial as CD34. Results Positive MK Immunostaining was detected in 77.8% of esophageal carcinoma,MVD was 40.43±6.27 in esophageal carcinoma positive for MK while it was 31.34±3.89 in esophageal car...