Abstract: Objective 　To study the clinical and pathological characteristics, subtypes and immunophenotypes of nodular fasciitis. Methods 　The histopathological features of 35 cases of nodular fasciitis were observed using light microscopy and immunochemistry, then clinical data was analyzed and the literature was reviews. Results 　Nodular fasciitis (NDF) occurs in all age groups but more often in young adults of 20 to 40 years old. The lesion is usually any part of the body's subcutaneous and of ten locates in upper extremity and trunk, clinically, NDF typically grows rapidly and of ten small sizes. Histopathologically, it is composed of plump fibroblasts or myofibroblasts, which of ten grow in S-shaped, fascicles or semicircinate pattern, lacking pleomorphic cells and easy to see mitoses. The lesion has loose and myxoid stroma, abundant vessels, ext ravasated red cells and irregular cranny, which is important features conduced to diagnose. Histologicly, there are 4 subtypes : myxoid NDF(10 cases), granulomatous NDF(15cases), giant cell NDF(2 cases) and fibromatous NDF(8 cases), which represent the disease's early, middle and later stages changes respectively. Immunophenotype demonst rates the vimentin, SMA and MSA are positive in tumor cells but S-100 and CD34 are negative. Conclusion 　NDF is a complex lesion, in which fibroblasts or myofibroblast s are hyperplasia and its component s are multiplex. So mastering the lesion's clinical features, histopathological configuration and immunophenotype can prevent the mistakes in diagnosis of sarcoma.