Abstract: Objective 　To study expressions and correlations of p53 、VEGF、MVD in NSCLC and discuss their significance in carcinogenesis and progression of lung cancer, as well as their relations with lymph node metastasis、angiogenesis. Methods 　56 surgically resected patient s with NSCLC combined with radiotherapy ±chemotherapy were enrolled in the study group . The expressions of p53 、VEGF and MVD were tested by immunohistochemical SP method. The result s were reciprocally analyzed and compared with lymph node metastasis、angiogenesis. Results 　Positive expressions of p53 、VEGF were found 55. 36 %(31/ 56) 、57. 17 %( 32/ 56 ) respectively. The mean MVD of the 56 cases was 25. 80 ±10. 55. There was significant positive correlation between MVD and lymph node metastasis ( P < 0. 001) . p53 、VEGF、MVD had significant positive correlation reciprocally ( P < 0. 001) . Conclusion 　p53 、VEGF and MVD had relationship with carcinogenesis and progression of NSCLC. p53 、VEGF and MVD had significant positive correlation. It was made clear that p53 、VEGF synergistic participated in the regulation of neoangiogenesis process. Significant positive correlation between MVD and lymph node metastasis indicated that there was probably relation between neoangiogenesis and lymph node metastasis, to some extent .