Abstract: Objective 　The goal observation oxalic acid platinum (L2OHP) unites the fluorine uracil (52 Fu), aldehyde hydrogen folic acid (LV) to take a plan t reatment later period colon cancer the clinical cur2 ative effect and the tolerance. Methods 　23 example later period colon cancer, the colon cancer 11 exam2 ples, the Rectal Cancer 12 examples, initially govern 8 examples, duplicate governs 15 examples, before the chemotherapy, passes through the elbow median vein leaving alone vein leaving alone needle. L2 OHP65 mg/ m2, the vein drop pours for 4 hours, d1 ; The LV200 mg/ m2 vein drop pours for 2 hours, 52 Fu0. 5 g/ m2 pushes the note af ter the CF dead center vein, continues continues the vein drop by 52Fu 2. 4 ～3. 0g/ m2 to pour for 48 hours, 21 days are 1 cycle, are used together 2 cyclical appraisal curative effect . According to WHO standard appraisal in the near future curative effect and poisonous side reac2 tion. Results 　The entire group patient s obtain the CR2 example, the PR9 example, effectiveness (CR +PR) 47. 8 %, initially governs effectiveness is 62. 5 %, duplicate governs effectiveness is 45. 4 %, statis2 tics processing not obvious difference ( P > 0. 05) . Main poisonous side reaction for disgusting, vomit (74 %), oral cavity mycodermatitis and diarrhea 59. 2 %, as well as a nerve ending exceptionally 55. 6 %. Conclusion 　The oxalic acid platinum unites the 52Fu/ LV plan t reatment later period colon cancer effec2 tiveness to be high, the tolerance is good, the untoward effect is light, is worth the clinical promotion.