膀胱癌患者血清可溶性FasL的测定及意义

Significance of serum soluble fas ligand in patients with bladder carcinoma

摘要: 目的　探讨膀胱癌患者血清中sFasL的意义。方法　用ELISA法测定 4 8例膀胱癌患者术前、术后及 2 5例健康献血员血清中sFasL的水平。结果　膀胱癌患者血清sFasL的水平为 12 .2 5± 1.16 μg/L。术前血清中sFasL含量显著高于术后 (P <0 .0 5 )及健康对照者 (P <0 .0 5 )。浸润性膀胱癌 (T2～ 4期 )血清中sFasL水平显著高于非浸润性膀胱癌 (T0～ 1期 ) (P <0 .0 5 ), G3 期膀胱癌血清中sFasL水平显著高于G1、G2 期膀胱癌 (P <0 .0 5 )。结论　膀胱癌患者血清中sFasL的水平与肿瘤的发生、发展有关。

Abstract: Objective To study the significance of serum soluble Fas ligand in patients with bladder carcinoma. Methods Sandwich enzyme linked immuno-sorbent assay (ELISA) was used to detect the level of sFasL in sera of 48 bladder carcinoma patients and 25 healthy donors. Results The level of sFasL in patients with bladder carcinoma pre-operation was 12.25 ± 1.16 μg/L. It was higher than that in patients after operation and that in healthy donors( P < 0.05 ). The level of serum sFasL in patients with muscle...