甲状腺乳头状癌微血管密度与VEGF、PD-ECGF表达的研究

Study on microvessel density and expressing of VEGF、PD-ECGF of papillary thyroid carcinoma

摘要: 目的　研究甲状腺乳头状癌 (PTC)的血管生成及VEGF、PD ECGF的表达, 并探讨其临床意义。方法　运用免疫组化方法检测 4 3例PTC, 10例甲状腺腺瘤和 10例正常甲状腺组织的MVD值和VEGF、PD ECGF的表达。结果　①PTC的MVD值和VEGF、PD ECGF的表达明显高于正常甲状腺组织 (P <0 .0 5 ) ;PTC的MVD值和VEGF的表达明显高于甲状腺腺瘤 (P <0 .0 5 ) ;甲状腺腺瘤的MVD值和VEGF、PD ECGF的表达明显高于正常甲状腺组织 (P <0 .0 5 )。②PTC的淋巴结转移状况与MVD值及VEGF的表达成正相关 (P <0 .0 5 )。结论　血管生成在PTC的发生、发展中占有重要的地位。

Abstract: Objective To investigate the angiogenesis and expression of VEGF、PD-ECGF of PTC,and discuss the clinical significance. Methods Detection the MVD and expression of VEGF、PD-ECGF in 43 PTC、10 thyroid adenoma and 10 normal thyroid tissue by immunohistochemistry. Results ① MVD and expression of VEGF、PD-ECGF of PTC were significantly higher than those of normal thyroid tissue ( P < 0.05 ); MVD and expression of VEGF and of PTC were significantly higher than those of thyroid adenoma ( P < 0.05 ); MVD an...