环氧化酶-2在乳腺浸润癌中的表达及临床意义

Expression of Cyclooxygenase-2 in Human Breast Invasive Carcinoma and Its Significance

摘要: 目的　研究环氧化酶 2 (COX 2 )在乳腺浸润癌中的表达情况及其与乳腺癌临床病理特征的关系。方法　应用免疫组织化学 (SP法 )检测 83例乳腺浸润癌 (其中有周围组织浸润 6 2例, 伴腋淋巴结转移 4 7例 )和 35例癌旁组织中COX 2的表达。结果　COX 2在乳腺浸润癌中的阳性表达率为 73.5 %(6 1/ 83), 显著高于癌旁组织 (P <0 .0 0 1) ;乳腺浸润癌组织COX 2的表达与临床分期、周围组织浸润和淋巴结转移密切相关, (P <0 .0 5, P <0 .0 5, P <0 .0 0 1), 与患者年龄和肿瘤大小无明显相关性。结论　COX 2蛋白表达可能在乳腺浸润癌的发生、发展中起重要作用。

Abstract: Objective To study the expression of cyclooxygenase -2(COX-2) in breast invasive carcinoma and its clinicopathologic significance. Methods The expression of COX-2 was detected with SP immunohistochemical analysis in 83 cases of breast invasive carcinoma (including 62 cases with surrounding invasion,47 cases with lymph node metastasis) and 35 non-cancerous specimens. Results The positive rate of COX-2 in breast invasive carcinoma was 73.5% (61/83),which was significantly higher than those in non-cancerous...