联合检测nm23-H 1、E-cadherin 基因蛋白在鼻咽癌中的表达

A Study of the Expression of Nm23-H1 and E-Cadher in Gene in Nasopharyngea l Carcinoma and Their Correlation with Tumor Metastasis

摘要: 目的　探讨 nm2 3- H1基因和粘附分子 E- cadherin在鼻咽癌中的表达情况及其与转移的关系。方法　用免疫组化 SP法检测 nm2 3- H1和 E- cadherin基因产物在 42例鼻咽癌中的表达。结果　 42例鼻咽癌活检标本中, nm2 3- H1蛋白表达阳性率 5 4 .7%, E- cadherin表达阳性率 5 7.1 %, nm2 3- H1蛋白在有颈淋巴结转移患者中表达阳性率为 40 .7%, 在无颈淋巴结转移患者中表达阳性率为 80 .0 %, 两者差异有显著意义 ( P<0 .0 5 )。E- cadherin在颈淋巴结转移阳性患者中表达阳性率为 44.4%, 颈淋巴结转移阴性患者中表达阳性率为 80 .8%, 两者差异有显著意义, ( P<0 .0 5 )。两种基因产物表达在鼻咽癌中呈正相关 ( P<0 .0 1 )。结论　nm2 3- H1和 E- cadherin基因与鼻咽癌的转移密切相关, 对临床判断鼻咽癌预后有一定指导意义.

Abstract: Objective To evaluate the role of nm23 H1 and E cadherin gene expression in nasopharyngeal carcinoma. Methods The S P immunohistochemical method was used to detect the expression of nm23 H1 and E cadherin. Results In 48 cases of nasopharyngeal carcinoma,Positive staining rate of nm23 H1 and E cadherin were 54.7% and 57.1%,respectively.nm23 H1 expression in the NPC with cervical lymph node metastasis and without cervical lymph node were 40.7% and 80.0%,respectively ( P<0.05 ).Th expression of E c...