髓母细胞瘤X线与质子适形放射治疗计划比较

Comparison between Proton and X-ray in the Treatment Planning of Patients with Medullo Blastoma

摘要: 目的对髓母细胞瘤患者用X线和质子适形放射治疗计划进行比较,寻求髓母细胞瘤更好的放射治疗方法。方法采用Eclipsephoton光子治疗计划系统和Eclipseproton7.3.2质子治疗计划系统对5例髓母细胞瘤患者设计放射治疗计划并进行比较。全脑全脊髓剂量36Gy,后颅窝局部加量至54Gy。用剂量体积直方图(DVH)比较正常组织受照剂量的差异。结果X线与质子适形放射治疗计划相比,右侧耳蜗90%的体积平均受照剂量分别为后颅窝加量野的39%和1.6%,右颞颌关节90%体积平均受量分别为26.1%和0.4%,50%心脏平均受照剂量分别为脊髓野处方剂量的63.3%和0.8%,90%甲状腺平均受量分别为72.2%和0.5%。结论质子适形放射治疗髓母细胞瘤可明显减少正常组织的受照剂量,优于X线适形放射治疗。

Abstract: Objective To compare the treatment plans between X-ray comformal radiotherapy and proton radiation therapy (PRT) for patients with medulloblastoma,to obtain a better technique in the treatment of medulloblastoma. Methods Five patients with medulloblastoma were chosen in the study.Using the Eclipse photon 7.3.2 and Eclipse proton 7.3.2 treatment planning systems from Varian,two different methods of radiotherapy planning: X-ray conformal planning and proton conformal planning were designed for the patients.The...