Abstract: Objective 　To explore the clinical value of anatomical variation of hepatic artery in interventional therapy for HCC. Methods 　This article ret rospectively analysed and compared hepatical arteriograph result s with clinical data and follow-up result s of 150 patient s with intermediate or advanced HCC, ret reated by TAE or TAI. Results 　Of 150 cases, there were 23 cases with anatomical variation of hepatic artery, and the ratio is 15. 3 %. Conclusion 　It indicated the incidence of anatomical variation of hepatic artery is relatively high. Meanwhile, the localization variation of hepatic artery, although without const ructional variation, had noticeable influence on hepatic artery catheterization. The author summarized the const ructional and localization variation types of hepatic artery, and discussed their significance in interventional therapy for HCC.