血清IL-12、IFN-γ、VEGF在急性白血病中的表达及其意义

Expression of Serum IL-12,IFN-γ,VEGF Level in Acute Leukemia and Its Significance

摘要: 目的　探讨急性白血病患者血清白细胞介素 12 (IL 12 )、干扰素 γ(IFN γ)和血管内皮生长因子(VEGF)的变化及其意义。方法　应用酶联免疫法测定急性白血病患者IL 12, IFN γ, VEGF化疗前后血清的水平, 并与正常对照组比较。结果　化疗前急性白血病患者血清IL 12, IFN γ低于对照组, VEGF高于对照组 (P <0 .0 1), 化疗后达完全缓解 (CR)时血清IL 12, IFN γ水平升高, VEGF水平下降, 与正常对照组无明显差异 (P >0 .0 5 )。结论　急性白血病患者血清IL 12, IFN γ, VEGF的变化可能与白血病细胞的生长及机体抗肿瘤免疫功能受损有关。

Abstract: Objective To evaluate the change of serum IL-12,IFN-γ,VEGF in acute leukemia and its significance. Methods Serum levels of serum IL-12,IFN-γ,VEGF were detected before and after being treated in cases of acute leukemia utilizing ELISA method, and compared with normal control group. Results The contents of IL-12 and IFN-γ were significantly lower (P< 0.01), while the content of VEGF was significantly higher (P< 0.01) in acute leukemia patients at the time of diagnosis than in the control subjects. ...