BAI新辅助化疗联合手术治疗老年局部晚期非小细胞肺癌
Clinical Study of Interventional Neoadjuvant Chemotherapy Combining with Surgery Resection to the Aged with Locally Advanced Non-Small-Cell Lung Cancer
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摘要: 目的 观察BAI(支气管动脉灌注 )新辅助化疗治疗老年局部晚期 (Ⅲ期 )非小细胞肺癌(NSCLC)的临床和病理组织学疗效以及对提高手术切除率的作用。方法 78例老年局部晚期NSCLC患者随机分为 2组 :(1)BAI化疗组, 先给予 1～ 2个疗程的BAI化疗后进行手术治疗 ;(2 )单纯手术组, 确诊后直接手术。结果 BAI化疗组的临床有效率和病理组织学有效率均为 5 0 .0 %。完成 2个疗程BAI化疗患者的临床和组织学有效率均高于 1个疗程的患者 (P <0 .0 5 )。但以影像学变化为判定标准的临床疗效与组织学疗效并不完全一致。BAI化疗组的手术切除率 (84 .2 % )和完全性切除率 (5 5 .3% )均显著高于单纯手术组 (分别为 6 0 .0 %和 30 .0 %, P <0 .0 5 )。结论 老年局部晚期NSCLC进行BAI新辅助化疗可获得良好的临床和病理组织学疗效, 且以 2个疗程BAI化疗的疗效为佳。BAI新辅助化疗可提高老年局部晚期NSCLC的手术切除率和完全性切除率。Abstract: Objective To observe the clinical and pathohistological response and effect of BAI (bronchial artery infusion) neoadjuvant chemotherapy on surgery resection rate in the aged with locally advanced (stage Ⅲ) non-small-cell lung cancer(NSCLC). Methods 78 cases of the aged with locally advanced NSCLC were randomly divided into two groups: (1) BAI chemotherapy group received BAI chemotherapy in 1～2 courses and followed surgery;(2) surgery alone group was treated by operation alone. Results In BAI chemotherapy g...
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