四川盐亭核黄素盐干预试验红血球谷胱甘肽还原酶活性系数的动态变化

Dynamic Change of Erythrocyte Glutathione Reductase Active Coefficient(EGRAC) Result from Riboflavin-fortified Salt Intervention Test in Yanting

摘要: 目的用核黄素强化盐对盐亭县居民进行核黄素的补充,评价服用强化盐后的核黄素营养改善情况,为使用强化盐预防食管癌提供依据。方法选取食管癌高发区四川盐亭地区的六个乡所有居民作为研究对象,试验组3万人,对照组3万人。试验组服用核黄素强化盐(核黄素150mg/kg);对照组服用同一批未添加核黄素的普通食盐。采用整群抽样的方法每年分别选取试验组和对照组的部分研究对象,测定红血球谷胱甘肽还原酶活性系数(EGRAC)评价核黄素营养状况。结果1991~1995年共采血1199人份,男性583人份,女性616人份。试验组抽样总体EGRAC平均值为1.09,对照组为1.32,差异具有显著意义,P<0.01。性别和年龄对核黄素的补充均没有影响。结论核黄素强化盐能显著改善核黄素营养状况,是一种经济、简便和有效的营养干预手段。

Abstract: Objective Riboflavin-fortified salt was supplemented in the dietary for residents in Yanting area in order to monitor the improvement of riboflavin. Methods 150mg riboflavin was supplemented per kilogram of table salt in the test group,while the common salt was used in the control group. Thirty thousand residents were included in both groups. The level of riboflavin was monitored through the measurement of erythrocyte glutathione reductase activity coefficient (EGRAC). Results The mean values general EGRAC ...