山西省阳城县宫颈癌危险因素研究
Analysis of Risk Factors for Cervical Cancer in Yangcheng County
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摘要: 目的 研究影响我国宫颈癌高发区宫颈癌发生的危险因素, 为宫颈癌防治工作提供依据。方法本研究建立在山西省阳城县宫颈癌筛查方法比较研究基础上, 采用了横断面调查方法。所有病例都经病理组织学确诊。HPV的检测是应用第二代杂交捕获试验对妇女宫颈细胞进行检查。资料采用VFP软件进行录入和整理, 利用 χ2 检验和非条件Logistic回归模型分析危险因素与宫颈癌的关系。结果 共 32 33名妇女参加了本次研究, 该人群HPV总检出率为 30 .4 %, 宫颈癌 (宫颈高度病变以上, ≥CIN3)的高危型HPV感染率为 99.0 %, 正常为 2 4 .0 %。宫颈癌患病率越高的村, HPV感染的危险度比值比越大, 与 <1.31组相比, 1.31～ 3.70和 >3.70组OR分别为 1.14 (0 .94～ 1.37)和 1.4 4 (1.19～ 1.73)。单因素分析与宫颈癌相关的因素有HPV感染、生产次数 (1/≥ 3)和宫颈糜烂、息肉, OR分别为 30 7.5 (42 .8～2 2 0 9.2 )、2 .4 4 (1.16～ 5 .14 )和 1.5 6 (1.0 3～ 2 .35 )。多因素非条件logis...Abstract: Objective To investigate the risk factors and provide the basis for prevention of cervical cancer. Methods The data based on a cross-sectional screening study in Yangcheng County, Shanxi Province, where cervical cancer was very popular. All cases were confirmed by pathology. The cervical cytological samples were collected by self-sampling and direct sampling methods. The high risk human papillomavirus (HPV) DNA was analyzed by Hybrid Capture Assay (HC?-II). All data was managed by Foxbase. χ 2 test and unc...
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