Effects of Vinorelbine Combined with Xeloda in Anthracycline- and Taxane-pretreated Patients with Relapsed Metastatic Breast Cancer

Objective To evaluate the short-term efficacy and adverse reactions of vinorelbine combined with xeloda to patients with recurrent and metastatic breast cancer after taxane and anthracycline treatment. Methods Forty patients with recurrent metastatic breast cancer after taxane and anthracycline treatment were recruited. Vinorelbine 25 mg/m² on day 1 and day 8, capecitabine 1 000 mg/m²,twice daily on day 1 to 14.Three weeks was one cycle.At least two cycles were given to each patient. Results Of the 40 patients,3 achieved CR,17 achieved PR,16 achieved SD,4 achieved PD,with a total response rate of 47.5%, with a clinical benefit response 70%.The median time to disease progression was 8.5 months.The common adverse reactions were myelosuppression，gastrointestinal reactions,hand-foot syndrome and neurotoxicity. Conclusion vinorelbine combined with capecitabine is an effective rigmens in the treatment of patients with relapsed and metastatic breast cancer,especially for those who have failed in chemotherapy with taxane and anthracycline.The therapy is well tolerated but has mild adverse reactions．