Expression and Significance of TRAIL and Its Receptors in Breast Cancer

Objective To study the expression and receptors（DR4，DR5，DcR1，DcR2） of TRAIL in breast cancer tissues. Methods Expression of TRAIL and its receptors（DR4，DR5，DcR1，DcR2）were assayed by reverse transcriptase polymerase chain reaction(RT-PCR） in 60 breast cancer tissues and corresponding normal breast tissues. Results The expression of TRAIL and its receptors（DcR1，DcR2）were lower in breast cancer tissues than those of normal breast tissues (P＜0.05).The expression of TRAIL and its receptors（DR4，DR5，DcR1，DcR2）showed no correlations to the tumor grade and clinical stage (P＞0.05). Conclusion TRAIL and its receptors play an important role in the apoptosis of breast cancer.The low expression of TRAIL and the loss of the decoy receptors（DcR1，DcR2）in breast cancer may be concerned significantly with its pathogenesis.